Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment.
نویسندگان
چکیده
Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens.
منابع مشابه
Antimicrobial Agents
Use of Nonlinear Mixed-Effects Analysis for Improved Precision of Early Pharmacodynamic Measures in Tuberculosis Treatment Geraint R. Davies,* Richard Brindle, Saye H. Khoo, and Leon J. Aarons Wellcome Trust Centre for Clinical Tropical Medicine, University of Liverpool, Liverpool, United Kingdom; Department of Clinical Microbiology, Portsmouth Hospitals, Portsmouth, United Kingdom; Department ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 9 شماره
صفحات -
تاریخ انتشار 2006